The face and neck provide the first clues to age, through pigment and texture changes, wrinkles, and sagging skin. A closer look at the current therapeutic options available to lessen these signs of aging will demonstrate that you do not have to play the cards nature has dealt.. In this guide, the medical options for restoration of the skin are reviewed, showing you how advances in medical technology make it possible for you to look your best. A number of medical options are currently available for the removal or reduction of wrinkles. Some involve regular application of a medicated cream or lotion to the face (topical agents), while other methods require surgical procedures.